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Interruption of mDLL4:hNotch1 binding assay



Figure 1. Since no mouse Notch-1 protein available, human and rat Notch-1 protein are used here.  Titration of mouse hDLL4 in the presence of different fixed amount of  hNotch-1 or rat Notch-1 . Apparent Kd for hNotch1 or rat Notch-1 and hDLL4 binding is around 5 nM.


 


Figure 2.  No commercially available positive controls available. Direct evaluation of compounds resulted in positive leads. Human Notch-1 is used in this experiment and the use of rat Notch-1 resulted in similar results.


 

Kits Components:       

 

-Pair of antibodies


 

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